MLB DFS Picks, Spotlight Pitchers & Top Stacks: Cleveland Rocks! (Sept. 21)

Saturday’s MLB action is coalescing around a featured-slate with a 7:05 p.m. ET first pitch on DraftKings, FanDuel and Yahoo. Today we’re exploring the MLB DFS projections with Stokastic’s industry-leading tools to uncover how to build MLB DFS stacks, identify top pitchers and craft optimal daily fantasy baseball lineups. Carlos Rodon stands out as the lead pitcher, with the Cinderella story of Ronel Blanco looking to get another chapter. According to the Stokastic MLB DFS Top Stacks Tool, the Cleveland Guardians and the Houston Astros are key targets for MLB DFS picks.

MLB DFS Picks: Spotlight Pitchers and Top Stacks | Sept. 21

Editor’s note: Stokastic’s NEW Pick’em Package!

Elevate your pick’em game with Stokastic’s premium projections! Our Pick’em package includes the PrizePicks Optimizer, making it easy to build +EV entries. Whether you’re a seasoned pick’em pro or just getting started, our tools and expert insights offer unbeatable value.

For a limited time, use promo code PICKEM25 to save 25% on Stokastic’s Pick’em Tools for PrizePicks, Underdog and DraftKings Pick6!

Don’t miss out on this deal as the sports action heats up!


MLB DFS Picks: Spotlight Pitchers

Main Slate Primary Pitching Target: LHP Carlos Rodon (NYY at OAK)

Yankees at Athletics – 3.4 implied runs
First Pitch: 9:40 p.m. ET
$9,300 at DraftKings
$10,400 at FanDuel
$49 at Yahoo

The Stokastic MLB DFS Top Pitchers tool begrudgingly looking to hop back on the LHP Carlos Rodon rollercoaster. Yahoo and FanDuel have assigned him the same salary cap figures as Cole received yesterday, while DraftKings gave him a $300 bump.

Rodon has allowed a home run in 20 of his 30 (67%) starts, with seven (23%) resulting in multi-home run efforts by the opposition. Strikeouts remain his colling card, with 10.23 per nine innings a tick above his career rate and his 2.86 walks per nine almost half a free pass below his traditional average. Over his last four games, he has allowed five home runs, with seven walks and a wicked 33 strikeouts in 23 innings.

The active roster for Oakland, leads the league with a .206 ISO against southpaws this season, which is beyond elite. However, the team is fifth with a 25.8% strikeout rate and 28th with a .292 on base percentage. Empty extra-base hits and solo home runs are something that Rodon can easily offset with his strikeout upside.

Main Slate Secondary Pitching Target: RHP Ronel Blanco (HOU vs. LAA)

Astros vs. Angels – 3.2 implied runs
First Pitch: 7:10 p.m. ET
$9,500 at DraftKings
$9,200 at FanDuel
$43 at Yahoo

RHP Ronel Blanco started off the season in style with a no-hitter. The 30-year-old began his baseball journey with Houston back in 2016, finally getting a cup of coffee as a reliever in 2022. Last year he was a spot-starter, while working out of the bullpen, but nothing — especially his 35 FV rating as a prospect — indicated this level of success.

Currently, Blanco ranks fifth overall with his 2.88 ERA, while also recording nearly one strikeout per inning. He does allow power to lefties (.207 ISO, 423 batters faced), with a 35.6% fly ball rate. Fortunately, he will only need to navigate the likes of Nolan Schaunel, Niko Kavadas and Mickey Moniak. The projected lineup for Los Angeles also has a 23.5% strikeout rate against right-handed pitching this season, while also rolling out three inexperience youngsters in Kavadas, Eric Wagaman and Gustavo Campero.

MLB DFS Picks: Top Stacks

Main Slate Primary Target: Houston Astros

Astros vs. Angels – 4.6 implied runs
First Pitch: 7:10 p.m. ET
Opposing Starter: LHP Reid Detmers
DK Top Stack %: 8.2%
FD Top Stack %: 7.8%

The Stokastic MLB DFS Top Stacks Tool is giving high marks to the Dodgers, who are at home against RHP Cal Quantrill, who has handed out 11 walks in his last eight innings, with only four strikeouts. The Yankees are also getting high marks in Oakland, taking on LHP J.P. Sears.

Houston is currently getting attention, but not enough for the cherry matchup against LHP Reid Detmers. The 25-year-old has split his season between Triple-A (5.54 ERA) and The Show (6.05). In his last start, the Chicago White Sox tagged him for seven runs, including a trio of taters.

The ChiSox have tallied 107 fewer runs than the next worst offense in the league and 232 below the Astros, which works out to 1.5 less runs per game. The active roster for the Astros has a 123 wRC+ against southpaws this season, which is the fourth most efficient collection of batsmen. Last night they tallied nine runs, including six off of LHP Tyler Anderson, who was not able to close out the third inning.

We can definitely go back to the well once more, with the ‘Stros providing options up and down the pricing sheet, representing every key position. The first wave to target is Yordan Alvarez and Kyle Tucker who crush same-handed hurlers. Tucker had been looking rusty after his lengthy injury layoff, but a four-hit night, with a solo shot and three runs scored, should go a long way to boosting his confidence.

Jose Altuve and Alex Bregman round out the core four, with catchers Yanier Diaz and Victor Caratini giving options at two different salary levels. Jake Meyers is a cheap power bat, as evidenced by his home run last night, with infielder Jeremy Pena also a desired target. Heck, even utility-man Maricio Dubon is in play as a discount dandy, with his past history of success against southpaws.

Main Slate Secondary Target: Cleveland Guardians

Guardians at Cardinals – 4.3 implied runs
First Pitch: 8:10 p.m. ET
Opposing Starter: RHP Miles Mikolas
DK Top Stack %: 5.5%
FD Top Stack %: 5.6%

The 4.3 implied run total has gamers shying away from Cleveland, though the matchup against RHP Miles Mikolas is a good one. The 36-year-old has allowed 18 runs in his last 15.2 innings, though three were unearned. He is under contract next year for $17.7 million, so we definitely do not have to say our goodbyes yet.

The best asset for Mikolas, is his ability to take the mound every time his name comes up in the rotation. He has made at least 30 starts in each of his last five healthy seasons, missing 2020 and getting just nine starts in 2021. Mikolas is basically pitching to contact this year, with only one walk in his last four starts and 6.39 strikeouts per nine innings, which is around his career-average, but amazing for opposing hitters and in turn, DFS stacks.

This season, Mikolas has allowed a .200 ISO to both lefties and righties, though the main focus should be on the left-handed hitters. Kyle Manzardo and Jhonkensy Noel are both lacking in experience, but certainly not power and with Mikolas not being a strikeout pitcher, this duo is popping in the model. Cleanup man Josh Naylor and switch-hitter Jose Ramirez are both profiling well against Mikolas’s pitch portfolio and even catch Bo Naylor looks like he could put one out of the park tonight.

Do not be overly concerned with the weather in St. Louis, as the current forecast has the potential afternoon showers, clearing by dinner time.

React App

 

LHP Reid Detmers is clearly in a funk. Despite a no-hitter as a rookie, he has spent quite a bit of time with the Salt Lake Bees in Triple-A. When he is locked in, he is a terrific mound presence, when he is not … well he gives up seven runs to the worst offense in the league.

The Portfolio EV model has the 25-year-old hurler for around 4.7 strikeouts tonight, which is a little higher than the 4.5 strikeouts being offered across various sportsbooks.

Currently, this opportunity stands out on DraftKings where it is available at +115 odds.

Portfolio EV shows this wager has +112 “true odds,” and while that is a slim ROI, the “plus” money aspect is nice, though also accounting for the 53% probability that the young-lefty gets to five strikeouts.

We can see that Pinnacle has a punitive -103 line, which works out to NEGATIVE 7% ROI. Be a savvy shopper!

Since returning from the minors, Reid has six, eight and 10 strikeouts, but he also has eight walks, four home runs and a 5.71 ERA in this stretch. The hope is that the Astros take care of business early, by putting the hammer down on Detmers.

With new wagers frequently appearing and disappearing as lineups are announced, having a Portfolio EV subscription is essential to seize every opportunity.

Final Thoughts for Saturday, Sept. 21

Aside from late afternoon showers in St. Louis, the featured-slate does not have any weather risks. Before locking in your MLB DFS picks, make sure to visit the top MLB Weather Report page for the latest updates as game time nears.

Eric "EMac" MacPherson won the 2007 Fantasy Baseball grand prize (trip for two to the MLB All-Star game) in the Roto format on ESPN. He won again in 2008, this time in the H2H format. As one of the early adopters of daily fantasy sports, EMac has been providing content for baseball and basketball as well as both professional and college football since 2012 for a variety of websites including DraftKings Playbook, FanVice, RotoWorld, Daily Fantasy Bootcamp, and RotoGrinders. He is well into his third decade of fantasy sports and has a wealth of knowledge and experience. Follow him on Twitter @EMacDFS or contact EMac by emailing [email protected].

Premium Data

MLB Data Central

Top Batters Tool: DraftKings

MLB DFS Top Stack % for FanDuel

MLB DFS Top Stack % for Yahoo

DraftKings MLB DFS Top Stacks Tool

DFS Winners from the Stokastic Community

Subscribe to the Stokastic newsletter

DFS advice, exciting promos, and the best bets straight to your inbox

Stokastic.com - Daily Fantasy Sports and Sports Betting Data, Tools, & Analytics

Please play responsibly. Only customers 21 and over are permitted to play. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.